Waking up with abdominal pain every day and lying down without pain may be due to duodenal ulcer, lumbar spine lesions, etc., which need to be combined with other symptoms and necessary auxiliary examinations to make an accurate judgment. Duodenal ulcer patients are prone to abdominal pain in the morning or fasting episodes, the typical patient’s abdominal pain has a certain degree of regularity and seasonality, and abdominal pain can be relieved to a certain extent after eating, in addition to abdominal pain, the patient may also appear nausea, acid reflux, black stools, and other symptoms, can be diagnosed by gastroscopy. Patients with lumbar spine pathology, such as lumbar spine fracture and lumbar disc herniation, usually show lumbar pain and activity limitation, etc. However, a small number of atypical patients may also show abdominal pain and discomfort, which can easily lead to misdiagnosis. Especially at night, poor sleep posture is more likely to aggravate lumbar spine disease, and the occurrence of morning episodes of abdominal pain, when lying on the side may help to alleviate the onset of such pain; usually need to be diagnosed through the lumbar spine MRI scanning and so on. When abdominal pain occurs, it is recommended to go to a regular hospital in time, under the guidance of the physician to carry out the necessary targeted examination, to clarify the cause of the disease, and timely targeted treatment.