General treatment and medication can be applied to infectious mononucleosis after discharge from the hospital with a cold. 1. General treatment Bed rest and intensive nursing care should be provided in the acute stage to avoid serious complications. When the spleen is obviously enlarged, strenuous exercise should be avoided to avoid rupture. Antibiotics can be used for secondary bacterial infection. 2.Drug treatment Patients with high fever can use antipyretics for symptomatic treatment. For sore throat, saline gargle or watermelon cream throat lozenges can be used. For high fever, severe sore throat, should pay attention to the pharynx secondary bacterial infection, can be treated with antibiotics under the guidance of physicians. Early treatment with interferon can relieve symptoms and reduce oropharyngeal detoxification, but it is not effective for latent EBV infections, and acyclovir or EBV-specific immunoglobulin can also be used for treatment. If infectious mononucleosis persists with a cold after discharge from the hospital, it is recommended that you go to the hospital as prescribed.