The reddish-orange mucous membrane at the outlet of the esophagus may be due to the metaplasia of the gastric mucous membrane at the esophagus caused by gastroesophageal reflux disease (GERD), gastroesophageal mucosal ectasia (GEME), Barrett’s esophagus (BES) and other diseases. 1. Gastroesophageal reflux disease (GERD): For patients suffering from GERD, due to long-term stimulation of gastric acid and inflammation, it may also cause stimulation of the mucosa at the outlet of the esophagus, which is manifested as the orange-red phenomenon. 2. Gastroesophageal mucosal ectasia: It refers to the appearance of gastric mucosa in the esophagus, which is often manifested as oval or round reddish-orange mucosa with clear edges during endoscopic examination. 3. Barrett’s esophagus: Normal esophageal mucosa is squamous epithelium, which is pink in endoscopy, but when the gastric epithelium is columnar epithelium, it will appear orange or orange-red in endoscopy, so when the squamous epithelium of the lower part of the esophagus is replaced by the columnar epithelium of the stomach, that is, it is Barrett’s esophagus, which manifests itself as the entrance of the esophagus with the phenomenon of red-orange mucosa. After the examination of the esophageal outlet with reddish-orange mucous membrane, it is recommended to consult a doctor in time, after the doctor’s interview, combined with the patient’s symptoms and the results of other related items, to clarify the specific causes of the disease, and to deal with the cause of the disease.