The causes of hypomelanosis mainly consider the following aspects: 1, considered as endocrine disorders, certain pathogenic factors lead to the body immune dysfunction, endocrine disorders, can produce anti-melanocyte antibodies, resulting in melanocyte damage, loss, induced vitiligo. 2, long-term outdoor workers, due to trauma, friction, etc., can also lead to melanin loss. 3, some drugs whitening products, the Can directly inhibit tyrosinase activity, do not let melanocyte synthesis, to achieve the purpose of whitening, common are tranexamic acid, glutathione, three seven seven. 4, some chemicals, such as insecticides, fungicides. 5, with age, the skin can appear aging, hair follicles within the melanocyte gradually reduced, also will appear melanin hypomelanosis.