The unbearable itching on the center of the foot may be related to ringworm of the feet, sweat herpes, and contact dermatitis, etc. In terms of treatment, the main target is to give antifungal, anti-allergic, anti-itching medication. 1. Tinea pedis: a skin disease in which the skin on the soles of the feet is infected with fungus. In addition to blisters, maceration, dry cracks, peeling and other symptoms, it will also be accompanied by varying degrees of itching, antifungal drugs such as itraconazole, ketoconazole can be cured by tinea pedis after treatment. When the itching is intense, it can be supplemented with anti-itching drugs such as oral chlorpheniramine maleate tablets. 2. Sweat blisters: also known as sweating eczema, with a variety of external factors related to stimulation, clinical manifestations of small blisters accompanied by intense itching symptoms, the treatment can be given to Dinaid cream, hydrocortisone butyrate cream and other anti-allergic drug therapy. 3. Contact dermatitis: refers to the soles of the feet skin because of contact with some kind of irritating substances occurring metamorphosis, usually unilateral onset, and may be accompanied by erythema, pimples or blisters, in the skin cleaning and disinfection, and then targeted to give anti-itching drugs, such as glycerine lotion, can improve the symptoms of itching. Excessive scratching and stimulation will aggravate the itching, and it is recommended that the patient go to the hospital in a timely manner and follow the doctor’s instructions to use medication, do not self-medication.