It is possible for blood creatinine to decrease from 350μmol/L to 200μmol/L. If the elevated creatinine belongs to chronic kidney disease, at this time the patient’s renal function decline more, after active treatment, such as lowering blood pressure, correcting various complications, can delay renal function damage, a small number of creatinine may be reduced from 350 μmol/L to 200 μmol/L, but the probability is not particularly large, at this time, the creatinine can be kept stable, generally indicates that the treatment effect is good. However, there is a special case, usually patients with chronic kidney disease creatinine is not particularly high, due to infection or application of nephrotoxic drugs and other factors lead to a sudden rise in creatinine to 350 μmol / L, this situation is called acute exacerbation of chronic kidney disease, this time, after removing the triggering factors, the creatinine may return to 200 μmol / L. If the increase is due to acute exacerbation, the creatinine may be reduced to 200 μmol / L. If the elevated creatinine is caused by acute kidney disease, such as urinary tract obstruction, diarrhea, gastrointestinal bleeding, drug-induced renal injury, etc., usually after active treatment and removal of the cause, the blood creatinine can be significantly reduced or even reduced to normal. Patients with elevated blood creatinine are advised to go to regular hospitals in time and follow the doctor’s instructions for standardized treatment.