Bone metastasis of prostate cancer is usually in advanced stage, and chemotherapy can usually control the progression of the disease and does not completely kill the cancer cells that have metastasized to the bone. Bone metastasis of prostate cancer is an advanced stage of cancer, and metastatic prostate cancer tends to develop into CRPC after a median remission time of 18~24 months with endocrine therapy, which is not dependent on hormones. Chemotherapy is an important treatment for CRPC, which can prolong the survival time of CRPC patients, control pain, reduce fatigue and improve the quality of life. Chemotherapy can kill tumor cells on a systemic scale and control disease progression, but it cannot completely kill tumor cells throughout the body. In addition, patients can also use endocrine drug therapy, local radiotherapy and so on. 1. Endocrine therapy:It can control both primary lesions and metastatic foci in bones, which is the most basic treatment principle. 2. Radiotherapy: internal radiotherapy with nuclide can be chosen for bone metastasis. Nuclide with isotope will selectively combine with bone metastasis and kill the cancer cells in the metastasis through radioactive rays to achieve the purpose of controlling the tumor. Bone metastasis of prostate cancer can be eliminated by chemotherapy to a certain extent, but it can’t kill the metastatic cancer cells completely, so it is suggested that patients should go to the hospital and follow the doctor’s instructions for comprehensive treatment.