General mild hypomagnesemia does not require special treatment. More severe hypomagnesemia treatment should include the following aspects: First, stop the intake of high magnesium drugs. Second, the application of calcium antagonism high magnesium, can be intravenous injection of calcium gluconate or calcium chloride. Third, can apply cholinesterase inhibitor, because the magnesium is too high, can make the nerve endings between the cholinesterase release increased, can apply neostigmine to inhibit the cholinesterase activity, reduce hypomagnesemia. Fourth, promote the excretion of magnesium, especially for patients with insufficient blood volume, can be supplemented with glucose or sodium chloride, intermittent application of diuretics to promote the excretion of magnesium. Fifth, renal replacement therapy, for patients with low urine output, such as renal failure, heart failure patients can promote magnesium excretion by hemodialysis, peritoneal dialysis, hemofiltration, etc.