Multifocal motor neuropathy is a progressive peripheral neuropathy with involvement of motor nerve ends, with the main clinical manifestation being asymmetric weakness of the distal extremities, heavier in the upper extremities, and generally unimpaired sensation. Treatment is primarily immunotherapeutic, and glucocorticoids, plasma exchange, and immunosuppressive agents may be considered. Many studies have shown that glucocorticoid therapy may be effective, but the efficiency is low. Plasma exchange is not effective in most patients, and individual patients may experience worsening of symptoms and deterioration of electrophysiologic markers. Immunosuppressive drugs are currently recommended, including cyclophosphamide as the first choice, which is used intravenously in high doses and then switched to oral treatment. Oral treatment alone is less effective, and symptoms will only slowly improve after 2-5 months of treatment.