Hepatomegaly is most common in patients with chronic hepatitis and cirrhosis, and is one of the common clinical manifestations in patients with liver disease. Hepatomegaly is mostly characterized by dry skin, dark and grayish face, and some patients may also have hyperpigmentation on the face and other exposed parts of the skin, especially around the eyes. These characteristic changes in the face of patients with liver disease are called “liver disease face”, which is due to liver dysfunction, resulting in increased melanin production. According to Chinese medicine, liver is the main color of green, people who drink alcohol for a long time, the liver is damaged, the face will naturally appear green or dark green, which is the so-called liver disease face, is the obvious manifestation of liver damage. The mechanism of liver disease appearance is not yet completely clear. Some scholars believe that the increase of estrogen in patients with chronic liver disease weakens the inhibition of tyrosinase by sulfhydryl groups in the skin, and tyrosinase increases the amount of tyrosine into melanin, which is deposited in the skin and darkens the skin.