Generally speaking, in the clinic, there is no uniform statement about how many years after kidney transplantation before a second transplantation is needed, whether another transplantation is needed and how many years between them need to be judged in conjunction with the patient’s first transplantation. For patients suffering from chronic renal failure, uremia and other serious kidney diseases, kidney transplantation can usually achieve better therapeutic effects than long-term maintenance of hemodialysis or peritoneal dialysis. Whether another kidney transplant is needed and how long the interval should be depends on the patient’s specific situation. If the first transplant has a good result and there is no kidney function abnormality, another transplant is usually not needed. If the result of the first transplant is not good and kidney failure occurs soon, the second or even the third transplant should be carried out as soon as possible, taking into account the patient’s recovery and whether rejection occurs. It is recommended to combine with the opinion of regular organ transplantation department or renal surgeon for judgment and early treatment so as not to delay the condition.