The causes of epidermal hyperkeratosis and hyperplasia include chronic inflammation, allergy, melanoma, etc.; anti-inflammatory (ketoconazole, erythromycin ointment), anti-allergy (benzylamine, etc.), and surgical treatments can be prescribed according to the cause of the disease. 1. Anti-inflammatory treatment: some pathogenic bacteria, such as fungi and gram-negative bacilli, infect the skin and mucous membrane, which can trigger inflammatory reaction and cause hyperkeratosis of epidermis and hyperplasia of the stratum spinosum. Clinical choice of ketoconazole, fluconazole, erythromycin ointment and other drugs for treatment. 2. Anti-allergic treatment: long-term stimulation of the skin allergens can cause local tissue edema, hyperplasia, resulting in local epidermal hyperkeratosis, spiny layer hyperplasia; contact dermatitis patients with the lesions of the localization of the above situation; this is due to the process of allergic reaction to release a large number of mediators caused by the need to use benzydamine, sodium cromoglycate, betahistine, menglust and other anti-allergic drugs for treatment. 3. Surgical treatment: when atypical hyperplasia occurs in the lesion tissue of epidermal hyperkeratosis concentrated hyperplasia, or melanoma is found in pathological examination, radical surgical excision treatment should be taken as soon as possible, and regional lymph node dissection should be done if necessary. In view of the specialized nature of the above drug use and surgical operation, it is recommended that the patient should first go to the hospital for examination, and under the guidance of the doctor, make a clear diagnosis before treatment.