Patient: Breast cancer resulting in now extensive bone metastases throughout the body. Two courses of chemotherapy and radiotherapy each. Now I can no longer walk easily and my left hand is fractured. How should I treat it? Shen Zhan, Department of Medical Oncology, Shanghai Sixth People’s Hospital: In addition to bone scan, it is better to have MRI examination to further confirm the diagnosis of breast cancer bone metastasis. Regarding the treatment, it includes systemic treatment and local treatment. If it is a systemic bone metastasis, then systemic treatment combined with local treatment is needed. If the metastasis is estrogen receptor positive, chemotherapy combined with endocrine therapy is recommended; local treatment includes bone cement, radiotherapy, gamma knife and surgery, etc. In addition, bisphosphonate therapy can be a more effective systemic treatment. In conclusion, breast cancer bone metastasis can be treated by more body means, but it must be treated appropriately. If the difficulty in walking is caused by bone metastasis in the spine, bone cementation can be considered; in addition, endocrine therapy can be used for systemic treatment. If the fracture has been broken, it is more troublesome to deal with it because the fracture is pathological and caused by the destruction of tumor cells, so it is necessary to deal with the local fracture site while trying to suppress the tumor cells.