The disadvantages of diploid rabies vaccine include difficulty in mass production, higher requirements for raw materials, and relatively expensive price. 1. Difficult to mass production, compared with animal cell rabies vaccine, diploid rabies vaccine needs more complex extraction and production process, so there is a certain degree of difficulty in large-scale mass production, can not be like animal cell rabies vaccine as large-scale production and application. 2. Higher requirements for raw materials, mainly reflected in the nutritional composition of bovine serum requirements, if the nutritional composition does not meet the requirements can not be produced, need to be carefully screened. 3. Relatively expensive, due to the complexity of the process, the production is relatively difficult, so the price is relatively expensive, such as the U.S. application of the diploid rabies vaccine 5 shots need to be about 10,000 yuan, the lack of applicability.