Children coughing in the middle of the night may be caused by gastroesophageal reflux, cough variant asthma, bronchitis and other diseases. 1. Gastroesophageal reflux: younger babies are prone to gastroesophageal reflux that irritates the back of the throat and triggers a cough due to the imperfect development of the cardia and the horizontal position of the stomach. 2. Cough variant asthma: cough variant asthma is a disease with cough as the main symptom, manifested as irritating dry cough, usually coughing violently, more obvious at night and in the early morning. Its etiology is currently thought to be more related to allergies and genetics. 3. Pertussis syndrome: Some babies with pertussis can also have paroxysmal spasmodic dry cough at night, which tends to be more severe. Need to improve pertussis nucleic acid PCR and other related tests to assist in the diagnosis. Clinical diseases such as upper respiratory cough syndrome can also lead to baby cough in the middle of the night, such as baby cough in the middle of the night, it is recommended that timely medical treatment, under the guidance of the doctor to be targeted treatment.