Hashimoto’s disease, also known as Hashimoto’s goiter or chronic lymphocytic thyroiditis, is an autoimmune disease and the most common cause of goiter combined with hypothyroidism. As a result of autoantibody damage, the diseased thyroid tissue is replaced by a large number of lymphocytes, plasma cells and fibrosis. A variety of antibodies such as antithyroglobulin antibodies, antithyroid microsomal antibodies and antithyroid cell surface antibodies can be detected in the serum. Excision of the specimen reveals extensive infiltration of thyroid follicular cells by lymphocytes and plasma cells, and the formation of lymphoid follicles and germinal centers. The disease is most commonly seen in women aged 30-50 years.