Iodixanol is a new type of clinical contrast agent, often widely used in a series of examinations to enhance CT, angiography, iodixanol its biggest side effect, there may be an allergic reaction. Clinical allergic reactions, common in the application of iodixanol within 10 minutes of the patient appeared facial flushing, urticaria, severe cases can appear shortness of breath, respiratory distress, and even life-threatening anaphylactic shock, other side effects include renal impairment, hepatic impairment, hyperthyroidism function abnormalities of patients with thyroid function has a certain impact. Therefore, it is necessary to comprehensively consider the patient’s situation, choose a reasonable contrast agent for treatment, to avoid these adverse side effects, especially renal function impairment and thyroid gland has lesions in the patient, try to avoid enhanced CT examination.