The causes of sudden heartburn and cold hands include overwork, panic attacks and hypoglycemic syndrome. 1. Overexertion: when overworked, staying up late for a long time, mental stress, and poor sleep quality, patients may experience transient discomfort, such as sudden heartburn and cold hands, which can be improved after resting. 2. Panic attack: it is an acute anxiety attack, often with a sense of near death and fear, usually relieved after tens of minutes, mostly accompanied by autonomic dysfunction, causing heart discomfort and cold hands. 3. Hypoglycemia syndrome: not eating regularly on time, dieting, etc. may lead to hypoglycemia, there will be dizziness, cold hands and feet, heart discomfort, and the symptoms will be relieved after replenishing sugar. Sudden symptoms of heart discomfort and cold hands may also be caused by other diseases. If this happens frequently and is not relieved by rest, you should seek medical attention.