Most of small cell neuroendocrine carcinoma of lung is very sensitive to chemotherapy, and some patients can achieve complete clinical remission through chemotherapy, but easy to recurrence and distant metastasis. Small cell neuroendocrine carcinoma of the lung is a kind of lung cancer with high malignant degree, which is very sensitive to chemotherapy, and after chemotherapy, some patients’ tumors can be significantly shrunk or even disappeared, that is to say, achieve complete clinical remission, only a very small number of patients are insensitive to chemotherapy, which belongs to the primary drug-resistant type. However, small cell neuroendocrine carcinoma of the lung is prone to recurrence and distant metastasis, and after the stage is decreased by chemotherapy, it is necessary to further evaluate whether there is distant metastasis. If patients are diagnosed with small cell neuroendocrine carcinoma of the lung, they should seek timely medical treatment and early treatment to prevent tumor metastasis and improve the prognosis actively.