Patients with pain in the middle of the upper abdomen may consider gastric cancer, but it may also be related to the patient’s prolonged improper diet or eating foods that are too cold, so it cannot be generalized. The location in the middle of the upper abdomen, i.e., under the glabella, may be related to benign lesions of the stomach such as gastric ulcer and duodenal ulcer if pain occurs there. Pancreatic-related diseases, such as acute attacks of acute pancreatitis and chronic pancreatitis; liver-related diseases, such as huge liver cysts and liver abscesses, can also cause pain in the middle of the upper abdomen in patients. Patients are recommended to go to the gastroenterology department of the hospital to improve relevant examinations, such as fiberoptic gastroduodenoscopy, hepatobiliary-pancreatic-splenic ultrasound, liver CT, pancreatic CT, as well as electrocardiogram, cardiac ultrasound, coronary angiography, etc., to clarify the diagnosis. After the cause of the pain in the middle of the upper abdomen is clearly identified, patients need to choose targeted treatment under the guidance of the doctor to control the condition.