Blood pressure has been unable to come down, you should look for whether there are secondary lesions, treatment of primary disease, appropriate adjustment of antihypertensive drugs, dietary control and so on. 1. First of all, it should be clarified whether the patient has secondary hypertensive lesions, such as chronic nephritis, primary aldosteronism, pheochromocytoma, etc. At this time, it is necessary to actively treat the primary pathology, such as treating chronic nephritis with glucocorticoid hormone, surgically treating primary aldosteronism and pheochromocytoma. After the primary disease is treated, the blood pressure can be controlled. 2. If it is primary hypertension, medication factors should be considered, such as whether the patient follows the doctor’s instructions for regular medication, whether the antihypertensive drugs are appropriate, and whether the drugs are adjusted through the effect of antihypertensive drugs. Antihypertensive drugs that have a long duration of action and a stable antihypertensive effect can be used, such as nifedipine extended-release tablets, amlodipine, etc., and several other antihypertensive drugs can also be combined, such as propranolol and irbesartan. 3. Lifestyle intervention, such as adopting a low-salt and low-fat diet, taking appropriate physical exercise, quitting smoking and drinking, going to bed early and getting up early, etc., may help control blood pressure after improving bad habits. If the blood pressure does not come down, you should go to the hospital as soon as possible and follow the doctor’s instructions for active treatment.