Bone alkaline phosphatase 250u/L is generally not serious, patients need to timely supplementation and prevention of rickets. Bone alkaline phosphatase, bone alkaline phosphatase is one of the phenotypic markers of osteoblasts, which can directly reflect the activity and functional status of osteoblasts, and it is a specific reference index mainly used for early diagnosis and subclinical differentiation of pediatric rickets in recent years, and it is also the best index currently used to evaluate the human body’s bone mineralization disorder. This index is mainly used to screen or assist in the diagnosis of osteocalcinosis caused by calcium malnutrition or other causes of metabolic bone disease. Its normal level should be less than or equal to 200u/L, while a bone alkaline phosphatase level of 250u/L is considered mildly high. Adults generally do not require special treatment, and regular monitoring of the condition is sufficient. In the case of children, vitamin D supplementation and, if necessary, oral calcium supplementation are required to prevent rickets. It is recommended that if the test result shows that the bone alkaline phosphatase is 250u/L, timely prevention of rickets and daily measures should be taken to prevent the condition from aggravating and causing serious impact on the child’s organism.