Patients experience pain in the bones after drinking alcohol for several common reasons: First, if there is a pre-existing inflammatory response in the skeletal area after drinking alcohol, drinking alcohol will cause the blood vessels to dilate, leading to increased inflammatory exudation, which can cause local skeletal pain symptoms, especially near the joints. Second, after drinking alcohol, a large amount of acetic acid will be produced, and acetic acid will accumulate around the bones, which will induce skeletal pain symptoms, usually soreness. Third, if the patient has a history of gout, drinking alcohol will trigger an acute attack of gout, which will also lead to severe pain symptoms in the bones involved in gout, usually accompanied by redness, swelling and increased skin temperature, and even the inability to bear weight, and a significant increase in serum uric acid in laboratory tests. Therefore, it is important to pay great attention to the pain in the bones after drinking alcohol, and early consultation and timely treatment can lead to rapid relief of clinical symptoms.