In pain management, physicians often apply a local anesthetic: lidocaine. It is a common belief that “lidocaine is only a narcotic. Once the time of anesthesia is over, it will not work and it will hurt again”, which is not true. First of all, the application of lidocaine during the nerve block in pain treatment also plays the role of “localization” of pain, if the injection position is correct, the pain will disappear immediately; if it does not disappear, either the injection position is not appropriate or there are other painful areas that have not been injected. Therefore, the role of lidocaine in pain management is not only anesthesia, but also the localization of the painful area. Secondly, lidocaine also has the effect of blocking the sympathetic nerve (involved in vasoconstriction – leading to metabolic disorders in the painful area, causing the accumulation of pain-causing substances and aggravating the pain), causing the blood vessels in the painful area to dilate and excrete excessive pain-causing substances through the blood circulation, thus reducing the pain. Its anesthetic effect is generally maintained for one hour, and its vasodilatory effect can be maintained for about 24 hours. In addition, analgesic drugs are compounded with other drugs such as non-steroidal anti-inflammatory drugs and vitamin B, in addition to lidocaine. Local injection therapy is applied: it is effective, with less systemic absorption and significantly fewer side effects than oral drugs and topical drugs. There are many patients with chronic pain for whom the application of antibiotic therapy is unfounded and often ineffective. Because chronic pain is mainly due to aseptic inflammation of soft tissues, not caused by bacteria, mycobacteria or viruses, treatment with antibiotics is ineffective!