Melasma can be treated by taking vitamin C, vitamin E, tranexamic acid and other medicines, and also with topical medicines as well as physical therapy measures. Chloasma is caused by many factors, such as ultraviolet radiation, cosmetic stimulation, endocrine disorders, genetic factors and so on. Oral medicines can be chosen to assist the treatment, such as vitamin C, vitamin E, and tranexamic acid. Among them, tranexamic acid itself is a drug that promotes hemostasis by inhibiting fibrinolysis, but it is clinically proved that it is more effective in improving chloasma by inhibiting the stimulation of some cytokines to melanocytes. Topical drugs can choose tranexamic acid paste, hydroquinone cream, compound arbutin cream and other drugs. Physical treatment can generally take Q-switched laser, which is generally able to remove melasma directly. Melasma needs to go to the hospital for examination first, and all drugs should be used under the guidance of professional doctors, especially oral drugs, to avoid serious adverse consequences caused by their own abuse of drugs.