The burning sensation in the stomach after an overdose of ibuprofen is first discontinued, and can be relieved by drinking plenty of water, and also by oral treatment with acid-suppressing drugs and mucosal protectants. Ibuprofen belongs to a kind of non-steroidal anti-inflammatory drugs, can provide antipyretic and analgesic, anti-inflammatory and other effects, can be used for the treatment of primary dysmenorrhea, gout, arthritis and other diseases and relief of pain symptoms caused by such diseases. The overdose of this drug may cause headache, vomiting, low blood pressure and gastrointestinal symptoms, first stop the drug, can be through more water to promote the discharge of drugs, can also be oral acid inhibitors and mucosal protective agent treatment, such as omeprazole, bismuth potassium citrate and so on. The occurrence of overdose of ibuprofen after the burning sensation in the stomach is recommended to go to the hospital, please doctor’s judgment, give treatment plan.