Weight loss in patients with high blood glucose may be caused by poor blood glucose control, hypoglycemic drugs, and the combination of other diseases, etc. It is recommended to consult your doctor. 1. Poor glycemic control: long-term poor glycemic control, the body can not fully utilize glucose for daily consumption, will accelerate fat and protein decomposition, resulting in weight loss. 2. Glucose-lowering drugs: such as metformin and other biguanides, or GLP-1 receptor agonists, such as liraglutide, etc. These drugs can effectively lower blood glucose when used in accordance with medical advice. However, these drugs may lead to weight loss. 3. Combination of other diseases: patients with high blood sugar combined with hyperthyroidism, gastrointestinal dyspepsia and other diseases, may also lead to weight loss. It is recommended that patients with high blood glucose who show signs of weight loss go to the hospital in time.