Pediatric itchy rash in early childhood, often occurring in papular urticaria or urticaria after the beginning of the wind or wind like pimples, and so the rash slowly subside, began to appear normal skin color, or reddish pimples, like mung beans or fava beans size, touch is relatively hard, the formation of itchy rash nodules, and sometimes there are blisters appeared. Children’s itchy rash mainly occurs in the extension of the limbs, especially the calves, calves shin front, can also occur on the stomach, buttocks, more serious patients can be systemic disease. Pediatric itchy rash rarely involves the metacarpal and bony fossa areas. The exact pathogenesis of pediatric itchy rash is being studied, and it may be related to individual genetic allergy, which often occurs simultaneously in several cases in one family, and other relationships with allergic reactions, autoimmunity, and psychiatric factors need to be further confirmed. Some studies have shown that the occurrence of the disease can also be facilitated by one’s own condition, social environment and malnutrition.