WHO histological staging (light microscopy) Ⅰ: including microscopic lesions, microscopic lesions with focal segmental hyperplasia, and focal hyperplastic glomerulonephritis (mild). Ⅱ:diffuse proliferative glomerulonephritis (mild),diffuse proliferative glomerulonephritis mild with focal segmental lesions significant. Ⅲ:Moderate focal proliferative glomerulonephritis,Moderate diffuse proliferative glomerulonephritis. Ⅳ:Diffuse proliferative glomerulonephritis severe, end-stage renal. International Society for the Study of Kidney Diseases in Children (ISKDC classification) I: No abnormality. Ⅱ:Simple thylakoid hyperplasia, a. focal, b. diffuse. III: Thylakoid hyperplasia with crescent formation <50%, a. focal, b. diffuse. Ⅳ: Thylakoid hyperplasia with crescent formation in 50%-75%. V: Thylakoid hyperplasia with crescent formation >75%, a. focal, b. diffuse. VI: thylakoid capillary nephritis (membranous proliferative nephritis). As seen above, the two types of staging are different, and the ISKDC histological staging is closely related to the prognosis and is more applicable to children and widely used. From the above staging, it is clear that the number of grade III or higher crescentic bodies is one of the factors affecting prognosis. It is common in acute nephritis and nephrotic syndrome. The common feature of immunofluorescence is immunoglobulin deposition, mainly in the thylakoid region, with varying degrees of capillary wall involvement. The presence of preparin and C3 in the thylakoid region, but the relative absence of C1q and C4, suggests that complement activation is achieved by the bypass pathway. Immunopathological typing: The glomeruli were divided into 4 types according to the immune complexes deposited in the glomeruli: IgA deposition alone (IgA type); IgA+IgG deposition (IgA, G type); IgA+IgM deposition (IgA, M type); IgA+IgG+IgM deposition (IgA, G, M type). There is also a correlation between immunopathological type and pathological grade, and there is a tendency for a higher proportion of IgA, M and IgA, G, M types to exhibit grade IV-VI pathology compared with IgA types alone. In particular, the higher incidence of grade IV-VI in IgA, G, M deposition type is also one of the reasons affecting the prognosis.