Recurrence of tongue cancer does not mean that there is no chance. Comprehensive treatment methods, such as chemotherapy and targeted therapy, are adopted according to the condition, pathology and staging. For advanced tongue cancer that fails local treatment, recurrence or distant metastasis, systemic chemotherapy is an important treatment means, that is, the efficacy may be limited, the remission rate of given combination chemotherapy is higher than the effect of single-drug treatment, but the toxicity is increased, which needs doctors to make comprehensive decision according to the condition and physical condition of patients. Targeted therapy to block epidermal growth factor, for patients who express epidermal growth factor receptor positive, cisplatin-based treatment failure of recurrent and or metastatic squamous cell carcinoma of the head and neck has certain efficacy. It may cause low neutrophils and low platelets, mucositis and so on. Recurrence of tongue cancer, it is recommended to visit the hospital for clear diagnosis and treatment.