There is no such thing as the best drug for whooping cough. Patients can be treated with macrolide antibiotics (such as erythromycin) as prescribed by their doctor. Pertussis is an acute respiratory infectious disease caused by the bacterium Haemophilus pertussis. After the diagnosis of pertussis is confirmed, patients can be treated with macrolide antibiotics, such as erythromycin, azithromycin, clarithromycin, and so on, as prescribed by the doctor. When the cough is severe, β2 agonists such as salbutamol can be taken orally. In daily life, patients should ensure sufficient rest and eat more nutritious and easily digestible food. Under the guidance of the doctor, appropriate therapeutic drugs must be selected according to the differences in the condition, and timely and full course of treatment can effectively control the progress of the disease. Regularly go to the hospital for review.