Thyroid nodules 40*30mm are relatively large and may cause a series of uncomfortable symptoms in the patient’s neck, and in serious cases, may have a tendency to deteriorate. Thyroid nodules are masses that appear after abnormal growth, usually located in the front of the neck, thyroid nodules may cause patients to experience discomfort. For nodules that have reached 40*30mm, they may cause squeezing and pressure on the patient’s neck, and the patient may experience pain, difficulty in breathing, difficulty in swallowing, shortness of breath and other symptoms. At this time, the nature of thyroid nodules should be clarified, for benign nodules, regular observation is needed, larger nodules need to be removed through surgery to reduce the pressure and discomfort; for malignant nodules, the preferred method of treatment is excision, and then may also need to take medication such as levothyroxine. It is recommended that patients with thyroid nodules seek medical attention in a timely manner and strictly follow the doctor’s instructions for treatment, not self-medication, nor should they be left unattended.