Long-term rubbing of povidone-iodine may lead to skin damage, dysbiosis, hyperpigmentation and other hazards. 1. Skin damage: As iodophor has strong oxidizing and disinfecting effects, if used for a long time, iodophor may cause damage to the stratum corneum of the skin and reduce the barrier function of the skin. 2. Bacterial dysbiosis: long-term use of iodophor can generally eliminate pathogenic bacteria, but at the same time may also eliminate normal bacteria, thus leading to bacterial dysbiosis. 3. Hyperpigmentation: Because the color of iodophor belongs to soy sauce, therefore, after long-term rubbing of iodophor, it may lead to the pigmentation on the wound surface, thus causing hyperpigmentation of the skin. It is recommended that patients standardize the use of iodophor and other drugs under the guidance of doctors to avoid adverse effects.