Calluses on the soles of the feet are medically known as calluses, mostly caused by excessive friction. If you want to remove the callus on the soles of the feet, you can follow the doctor’s instructions to use general treatment, drug treatment, physical therapy and other ways of treatment. 1. General treatment: patients should usually do a good job of foot skin care, reduce friction on the lower, wear comfortable and breathable shoes and socks, regular foot soak in warm water or hot compresses with a towel, soften the local keratin. 2. medication: patients can follow the doctor’s instructions for external use of retinoic acid cream and other retinoic acid drugs coated in the affected area to improve hyperkeratosis and eliminate calluses. 3. Physical therapy: patients can undergo liquid nitrogen cryotherapy, which accelerates the necrosis of the plantar skin tissue and promotes the elimination of callus through the rapid freezing of the local skin. If you want to eliminate the callus, it is recommended to consult the hospital in time and standardize the treatment under the guidance of the doctor.