Neurodermatitis and neuropathic itch can be differentiated in terms of cause, lesion manifestation, and site of onset. Neurodermatitis is generally believed to be related to neuropsychiatric factors, such as overthinking, impatience, tension, depression, etc., or local irritants, such as woolen fabrics, sweat impregnation. It is mostly characterized by paroxysmal intense itching in the neck, both elbows, lumbosacral area, scrotum, perianal area and other parts of the body, accompanied by mossy changes. Neurogenic itch is mostly geriatric itch, the main cause of dry skin, usually without primary skin injury, other mental neurological factors such as tension, anxiety and other emotional factors can also trigger this disease, which can be manifested as itching, can have burning, ants and so on. The appearance of the above symptoms is recommended to consult a doctor in time and follow the doctor’s instructions for treatment.