Thyrotropin-releasing hormone is usually increased if the pituitary gland is removed. Thyrotropin-releasing hormone (TRH) is produced by the hypothalamus and is mainly regulated by negative feedback from thyrotropin (TSH) secreted by the pituitary gland and thyroid hormone secreted by the thyroid gland. When the pituitary gland is removed, the decrease in TSH secretion will negatively feedback cause the hypothalamus to increase the synthesis and secretion of TRH, resulting in increased levels of TRH in the blood. In addition, dopamine, norepinephrine, sex hormones, melatonin and other hormones can also affect the secretion of TRH. Patients who have had their pituitary gland removed are advised to visit a hospital in a timely manner and to consult their doctor for more information.