There is no specific antihypertensive drug for differential pressure, you can choose amlodipine, valsartan, metoprolol and other drugs for treatment, the specific medication should follow the doctor’s instructions. Differential pressure is mostly seen in elderly patients with hypertension, patients with varying degrees of atherosclerosis, arterial vascular regulation of blood pressure decreased, can be manifested as differential pressure. There is no specific antihypertensive drug treatment for patients with high differential pressure, and the five first-line antihypertensive drugs commonly used in clinical practice are available, such as amlodipine, valsartan, metoprolol, hydrochlorothiazide, captopril and so on. Patients with mildly elevated blood pressure can choose a single drug treatment, and severe hypertension requires a combination of drugs, requiring oral treatment with more than two to three antihypertensive drugs. Patients with large differential pressure should choose antihypertensive drugs under the guidance of physicians and develop specific treatment programs.