Any disease that can lead to lower limb ischemia is always called lower limb ischemic disease, the common characteristic of these diseases is: they all have lower limb ischemia manifestations and signs: mild ischemia can be manifested as intermittent claudication, the affected limb skin temperature is low, cold and fear of cold. Moderate and severe ischemia can appear in the affected limb persistent pain, skin temperature becomes more cold, skin color from pale gradually become purple, or even black necrosis, the patient’s pain is often intolerable, in the cold and after the activity is more intense. If not treated in time, it will lead to amputation or even life-threatening consequences. The main types of these diseases include atherosclerotic occlusions, diabetic occlusions, arterial occlusions due to arteritis, and arterial occlusions due to blood clots. Lower limb ischemic diseases are not difficult to diagnose, but treatment is difficult and problematic. With the development of modern interventional technology, the lower limb ischemic disease has made revolutionary progress, which is introduced as follows: 1, clear cause and control of the original disease is a prerequisite: first of all, we have to clarify the cause of lower limb ischemia, only clear the cause of lower limb ischemia, we can have a target, and achieve good therapeutic effect. For example, for young people, especially young women, aortitis is an important cause of limb ischemia, but in the active phase of the lesion, we first need to control the aortitis, can not be directly balloon dilatation and other treatments. For the elderly, atherosclerosis and diabetes mellitus may be the main cause of lower limb ischemia, so we have to treat ischemia at the same time as the treatment of the primary disease, such as controlling the blood lipid and blood glucose levels. For young and middle-aged men, attention should be paid to the presence of trauma and smoking history, and those who are addicted to smoking must be persuaded to quit smoking, otherwise it will affect the therapeutic effect. In short, after the primary disease is clearly defined, the first step is to actively treat the primary disease, and then open the occluded blood vessels as soon as possible. 2, the early opening of blood vessels to restore blood supply is the key to the treatment: only through the blood vessels to restore the blood supply of the lower limbs, interventional technology is the best means of opening the blood vessels, it does not need to be opened, minimally invasive, through the thrombosis, balloon dilatation, stenting, atherosclerosis and other technologies can rapidly open the blood vessels to restore blood supply. Supply. In the past, surgical treatment required incision, artificial bypass and artificial blood vessel replacement have certain problems. Pharmacological treatment is slow in onset, not effective for plaque, even delayed treatment, and far less effective than interventional therapy in opening up blood vessels.3. Subsequent rehabilitation treatment is the guarantee of good therapeutic effect: medication is very important after opening up blood vessels, which includes thrombolysis, anticoagulation, activation of blood stasis, improvement of microcirculation, antioxidant, anti-infection, physiotherapy, etc. These treatments should be carried out at the same time upon admission to the hospital. These treatments should be carried out at the same time as soon as you are admitted to the hospital, and after opening the blood vessels, you can continue the treatment until you are fully recovered to ensure the treatment effect. In conclusion, lower limb ischemic disease must be diagnosed and treated early. Before treatment, the cause of the disease and the degree of stenosis and occlusion of blood vessels must be clearly defined. For moderate and severe ischemia, interventional therapy should be used as early as possible to open the blood vessels to restore the blood supply, and then cooperate with the drug therapy. Do not delay treatment, resulting in amputation or even life-threatening consequences.