Cardiac ST segment changes are generally analyzed according to the causes of ST segment changes, the main causes include physiological and pathological changes, which can be treated with medication and general therapy according to the causes. 1. Physiological: If patients have ST-segment changes of downward shift or elevation in ECG, it can be detected by ECG, and usually there are no symptoms. Cardiac echocardiography and cardiac CT examination are normal. This kind of cardiac ST-segment change usually does not need treatment and will not affect your health. 2. Pathological: Pathological changes in ST segment of the heart are mainly related to myocardial ischemia, heart attack and other diseases. When suffering from myocardial ischemia or myocardial infarction, it will lead to the phenomenon of ST segment downward shift or elevation, and then you need to take medication under the guidance of the doctor. When myocardial ischemia occurs, some calcium antagonists such as amlodipine and diltiazem can be used to improve the phenomenon of myocardial ischemia, while changes caused by myocardial infarction can be treated with some antiplatelet drugs such as aspirin and clopidogrel. If there are no clinical symptoms, ST segment changes may not require treatment, and maintain a healthy lifestyle. If there is panic and chest tightness, you can follow the doctor’s instructions to use medication according to the original disease; if the condition is more serious and the effect of medication is not good, then you can choose coronary intervention or surgical treatment. If discomfort occurs, it is recommended to go to the hospital for treatment in time to avoid delaying the condition.