The main reason why Greenbarin syndrome cannot be vaccinated is to prevent the occurrence of serious adverse reactions in the vaccinated person, which may lead to the aggravation of the condition. Guillain-Barre syndrome is an acute peripheral neuropathy characterized by symmetrical flaccid paralysis of the limbs. It is a rare disease in clinical practice and is caused by the immune system within the body launching an abnormal attack on the peripheral nerves, causing symptoms such as dyskinesia and dysesthesia. Although vaccination with a biological agent can be effective in preventing the disease, patients with Guillain-Barre Syndrome should not be vaccinated during their illness. Vaccination itself will stimulate the body’s immune system to produce appropriate antibodies, and the immune system of patients with Guillain-Barre Syndrome itself has abnormalities, so vaccination may aggravate the condition and cause serious adverse reactions. For patients with Guillain-Barre Syndrome, it is recommended that vaccination be considered after the body has recovered, and that patients should seek medical attention if they feel unwell.