Spironolactone and furosemide can be taken at the same time. Furosemide is also called a collaterals diuretic, which acts on the thick segment of the ascending branch of the medullary collaterals of the kidney, and is a strong diuretic. Spironolactone is also called potassium-conserving diuretic, which acts on the distal tubule of kidney and plays the role of potassium conservation by inhibiting aldosterone or inhibiting the sodium-potassium exchange pump, but its diuretic effect is weak, so it is not effective when applied alone. Adverse effects.