Itchy skin may be caused by a variety of etiologies and must be treated for the primary cause of the itch, for example, itchy skin may be due to diabetes, nephritis or jaundice, or itchy skin may also be due to allergies. The cause must first be treated, such as treating the underlying disease or removing the underlying allergen. At the same time, local scratching and rubbing should be avoided. In addition, topical medications, such as topical glucocorticoid creams, can be used in combination. In addition, certain drugs can be given orally or intravenously or intramuscularly in combination, such as oral antihistamines. Injections of glucocorticoids or calcium gluconate can also be used in combination to relieve itching quickly.