Although both ibuprofen and etoricoxib belong to the non-steroidal anti-inflammatory drugs, both have the effect of anti-inflammatory analgesic and antipyretic, but due to the slightly different mechanism of action of the two, the side effects are also different, can not be answered clearly. 1. Ibuprofen: mainly used for the treatment of arthralgia, headache, muscle pain, neuralgia, toothache and other pain reactions, but also for the common cold and influenza caused by fever to play a role in reducing fever. Symptoms such as nausea, vomiting, abdominal pain, diarrhea, constipation, indigestion, dizziness, drowsiness, allergies, yellowing of the eyes, tinnitus, and blurred vision may occur after use. It is contraindicated for those who are allergic to NSAIDs, pregnant and lactating women. Pay attention to avoid long-term or large amounts of use, and do not drink alcohol during the use of the drug. 2. Etoricoxib: It is mainly used to treat symptoms of osteoarthritis, acute gouty arthritis and chronic pain, primary dysmenorrhea. Fatigue, dizziness, nausea, lower limb edema, hypertension, vomiting, insomnia, allergy and other symptoms may occur after using the drug. It is contraindicated in people who are allergic to the components of the drug, people with active peptic ulcers or bleeding, pregnant women and lactating women should be cautious. Attention should be paid to shortening the duration of the drug as much as possible, reducing the dose, avoiding the combination with other non-steroidal anti-inflammatory drugs, monitoring the patient’s condition during the use of the drug. Comparatively speaking, ibuprofen gastric irritation is greater; etoricoxib gastric irritation is less; both or other NSAIDs will have side effects on the human body, and minimize the use of the drug or discontinue its use after slowing down the symptoms. Patients are advised to use the medication under the guidance of a doctor and avoid self-medication.