Abstract: Objective To compare the efficacy of laparoscopic cholecystectomy (LC) with laparoscopic cholecystectomy (LCPG) for gallbladder stones (polyps). Methods To retrospectively analyze the clinical data of 118 cases of LCPG and 118 cases of LC with similar age and the same disease type for the treatment of gallbladder stones and polyps in our hospital from January 2009 to June 2012, and to compare the operative time, intraoperative bleeding, time to exhaustion, operative complications, hospital days, hospital costs, postoperative complications and other surgical conditions and recent and long-term life of the two quality of life. In the biliary preservation group, one case underwent laparoscopic cholecystectomy 5 days after surgery due to biliary peritonitis caused by leakage from the gallbladder incision; the remaining 117 cases were operated successfully, with stones and polyps removed cleanly, with no intraoperative bleeding, biliary leakage, acute cholecystitis, pancreatitis, secondary common bile duct stones and incisional infection, and other postoperative complications. The 117 patients in the biliary preservation group were followed up for 3 to 45 months after surgery, with no dyspepsia, bloating or diarrhea, and no gallbladder cancer. 3 patients had a small number of recurrent sediment-like stones in the gallbladder at 3, 12 and 18 months after surgery, respectively, and were treated with cholestasis medication for 1 month after which the abdominal ultrasound showed that the sediment-like stones had disappeared. Among the 118 patients in the LC group, 115 had completed surgery, while the other 3 had open surgery due to injury to the common hepatic duct, gallbladder artery and duodenum. 115 patients in the LC group were followed up for 3 to 45 months after surgery, 9 had dyspepsia, 5 still had intermittent epigastric or right epigastric distension and discomfort, 7 had increased stool frequency and Intermittent diarrhea. LCPG is easier and safer than LC, with less intraoperative bleeding, better postoperative dyspepsia, bloating and diarrhea than LC, and better quality of life than LC group. The recurrence of stones and regeneration of polyps were rare in the LCPG group. Xu Xinbao, Department of Hepatobiliary Surgery, Air Force General Hospital