Causes of large spleen: 1, infectious factors, including acute infection and chronic infection. Acute infections are common in viral infections, rickettsial infections, bacterial infections, parasitic infections, spirochete infections; chronic infections are common in chronic viral hepatitis, chronic schistosomiasis, chronic malaria, black fever, etc.; 2, non-infectious factors, including bruising, hematological disorders, connective tissue disorders, histiocytosis, lipid deposition disorders, tumors and splenic cysts of the spleen. Clinically, splenomegaly should cause patients to pay enough attention.