Lung abscess is a necrotizing infection characterized by confined pus formation in the lung. Clinical symptoms mainly include fever, cough, coughing yellow pus sputum, night sweats, and wasting. The most common pathogens include anaerobic bacteria, streptococci, and Staphylococcus aureus. In immune-compromised patients, Nocardia, Mycobacterium and fungi are possible. How is lung abscess treated? The main antibiotics are used, and empiric dosing must cover anaerobic and positive cocci. Recommended regimens: 1. clindamycin 600mg q6h or q8h; 2. piperacillin/tazobactam 3-6g q6h; 3. ceftriaxone 2.0q12h + metronidazole 0.5q8h; 4. tylenol 1.0q6h + vancomycin 1.0q12h/linezolid 600mg q12h ( (The presence of drug-resistant bacteria is considered in severe disease). Pulmonary physiotherapy and postural drainage are not recommended and may lead to pus causing asphyxia and contamination of other lung tissues. Drainage is not recommended because patients can spontaneously drain thick sputum through a patent airway. Unless there is an obstructing factor in the airway that cannot be removed (e.g., tumor). Transbronchoscopic suction is usually not effective. Percutaneous puncture drainage or tube placement for drainage is ineffective and risky, and can easily lead to pneumothorax, abscess chest and bronchopleural fistula. Surgical intervention is rarely performed, in the form of lobectomy and total pneumonectomy. It is mainly performed for huge lung abscesses (larger than 6-200 px in diameter) that are not satisfactorily treated with antibiotics, multiple lung abscesses, lung abscesses that do not improve after more than 3 months of antibiotic therapy, and lung abscesses that produce serious complications (development of pneumothorax and bronchopleural fistula). The course of antibiotic therapy is not yet uniform. A minimum of 3-6 weeks is recommended until the imaging lesion disappears or only stable scar foci remain before discontinuing the drug.