The blisters on the root of the tongue may be caused by pemphigus, mucosal pemphigoid and other diseases, as follows. 1. pemphigus: autoimmune herpetic disease of the skin and mucous membranes, oral mucous membrane damage is easy to break through the blisters, break through the formation of vesicles, with a cotton swab rubbing the appearance of the normal mucous membrane, the mucous membrane surface blisters or blisters, or to make the appearance of the normal mucous membrane surface layer off. It can be accompanied by blistering damage of the skin. 2. Mucocutaneous pemphigoid: autoimmune disease, oral damage occurs in the mucous membrane blisters or blood blisters, blisters burst after the remaining white blister wall, and can form red vesicles. There may be other reasons for the blistering of the root of the tongue, if the above symptoms occur, it is recommended to go to the hospital in time, early targeted treatment.