Gastroesophageal reflux disease (GERD) is the uncomfortable symptoms and/or histologic changes caused by the reflux of food into the esophagus. 70% of patients have the typical symptoms of heartburn and reflux. If the disease is diagnosed or suspected, raise the head of the bed fifteen to twenty centimeters, should not eat again three hours before bedtime, do not lie down immediately after eating during the day, quit smoking, quit drinking, the belt should not be too tight, lose weight, do not eat high-fat foods, chocolate, coffee and stimulating foods. Oral non-steroidal anti-inflammatory drugs (including aspirin) on the stomach and duodenum damage is the most significant, its mechanism of action has a local effect and systemic effect. Although there are enteric formulations that can overcome the local effects of the drugs to a large extent, clinical studies have shown that dosage form changes do not significantly reduce the incidence of ulcers and complications associated with this class of drugs. Therefore, this class of drugs should be treated as little as possible, rather than listening to advertisements and believing that a change in dosage form is harmless.