Gastroesophageal reflux disease (GERD) refers to the reflux of gastroduodenal contents into the esophagus causing heartburn and other symptoms, and can cause reflux esophagitis and damage to tissues other than the esophagus such as the pharynx and airway. This disease is very common in western countries, 7%~15% of the population have GERD symptoms, the incidence rate in China is lower than that of foreign countries, the incidence rate in Beijing and Shanghai is 5.77%. The pathogenesis of GERD is mainly due to the dysfunction of the sphincter muscle in the lower esophagus and the dysfunction of the esophagus and the power of the stomach, which leads to the reflux of gastric contents into the esophagus, so that the gastric acid, pepsin, bile salts and other substances stimulate the esophageal mucous membrane, causing esophageal inflammation, erosions, and ulcers. This disease can coexist with hiatal hernia of the esophagus, chronic gastritis, peptic ulcer and other diseases, or it can exist alone. However, endoscopic manifestations of esophagitis can be absent in a significant proportion of patients. This type of GERD is also known as endoscopy-negative GERD or non-erosive reflux disease (NERD). Typical symptoms of GERD are acid reflux, regurgitation, heartburn, bloating, belching, and other GI symptoms, as well as coughing, coughing up sputum, laryngeal tightness, wheezing, non-cardiogenic chest pain, pharyngolaryngeal inflammation, rhinitis, otitis media, and aspiration pneumonia, which can seriously affect patients with extra-esophageal manifestations. Extra-esophageal manifestations, seriously affecting the quality of life of patients. In severe cases, upper gastrointestinal bleeding, esophageal subluxation, and Barrett’s esophagus occur. Patients’ symptoms worsen when eating acidic, high-fat foods and taking medications such as aspirin. Endoscopy is an accurate method of diagnosing reflux esophagitis, and 24-hour esophageal pH monitoring provides evidence of the presence of acid reflux. Lifestyle changes should be fundamental to treatment. Patients suffering from reflux esophagitis should change their lifestyles and dietary habits, avoid mental stimulation, avoid tobacco, alcohol, strong tea, coffee and sour and spicy foods, etc. Don’t lie down immediately after a meal, elevate the head of the bed by 15-20cm during sleep, and avoid a full stomach 3 hours before bedtime, which can reduce the occurrence of acid reflux. Pharmacological treatment can be applied ranitidine, omeprazole, lansoprazole, rabeprazole and other drugs to reduce the secretion of gastric acid, given to thioglycollate aluminum suspension gel, magnesium aluminum carbonate, calcium carbonate oral suspension and other gastric mucosal protectants, and can be added with morpholine, mosapride, itopride and other pro-dynamic drugs to promote esophageal peristalsis and gastric emptying, reduce reflux.