The statement of the 4 harbingers of hiccups is unscientific. Hiccups may be the result of gastrointestinal disorders, mediastinal disorders, central nervous system disorders, etc., but they may also be a transient and physiologic phenomenon. Hiccups are medically known as hiccups, which are caused by spasmodic contraction of the diaphragm after stimulation. It is usually caused by a transient spasm of the diaphragm due to eating too fast, too cold, too spicy, too full, etc., or by factors such as strenuous exercise, but this is usually physiological and can be recovered soon. However, if the patient has long-term or recurrent symptoms of hiccups, pathological factors should be considered. 1. Gastrointestinal diseases: when the patient has gastroesophageal reflux disease, peptic ulcer, chronic gastritis, intestinal obstruction, gastrointestinal cancer and other diseases, it may stimulate the diaphragm or phrenic nerve, vagus nerve and so on, which will cause diaphragmatic spasm and lead to hiccups. 2. Mediastinal diseases: such as myocardial infarction, pericarditis, mediastinal tumor, etc., which may also cause diaphragmatic spasm and make the patient have hiccups. 3. central nervous system diseases: such as meningitis, cerebral hemorrhage, stroke, brain tumors, etc., diseases, may stimulate the central nervous system, resulting in diaphragmatic spasm and hiccups. In addition, patients with pleurisy, lung cancer, pneumonia, gastrointestinal surgery, etc. may also experience hiccups. Therefore, if the patient has hiccups for a long time or repeatedly, it is recommended to consult a doctor in time to identify the cause of the disease and carry out targeted treatment.